How Safe Is Semaglutide?

Overall safety profile​

✔️ Well-studied — used in large clinical trials and real-world practice

✔️ Approved by regulators (UK, EU, US) for specific indications

✔️ Generally safe under medical supervision

⚠️ Safety depends on:

• dose escalation speed

• existing medical conditions

• concurrent medications

• ongoing monitoring

 

Common side effects (most frequent)

These are usually dose-related and often improve with time:

• nausea

• vomiting

• diarrhea or constipation

• bloating

• reduced appetite

• fatigue

👉 Most people experience mild to moderate effects during the first weeks.

 

Less common but serious risks

These are rare, but essential:

• Pancreatitis (inflammation of the pancreas)

• Gallbladder issues (gallstones due to rapid weight loss)

• Severe gastrointestinal intolerance

• Dehydration if vomiting/diarrhoea is persistent

 

Who should NOT use semaglutide?

Semaglutide is not recommended for people with:

• personal or family history of medullary thyroid cancer

• MEN2

• severe gastroparesis

• active pancreatitis

• pregnancy or breastfeeding